Complement and meningococcal infection.
نویسندگان
چکیده
منابع مشابه
Meningococcal meningitis and complement deficiences
Results A hundred and twenty nine patients (69M:60F) were included in the study. The age of the patients ranged from 2 months (m) up to 64 years old (mean= 96.2m; median=48m). The following serogroups were identified: type C, 36.4%; B, 20.2%; W135, 1.5% and 41.9% had no serogroup identified. CH50 and AP50 values were below the reference levels in 48 patients (37.2%) and 97 patients (75.2%), and...
متن کاملMeningococcal disease and the complement system
Despite considerable advances in the understanding of the pathogenesis of meningococcal disease, this infection remains a major cause of morbidity and mortality globally. The role of the complement system in innate immune defenses against invasive meningococcal disease is well established. Individuals deficient in components of the alternative and terminal complement pathways are highly predisp...
متن کاملInvestigation for complement deficiency following meningococcal disease.
BACKGROUND AND AIMS The incidence of complement abnormalities in the UK is not known. It is suggested in at least three major paediatric textbooks to test for abnormalities of the complement system following meningococcal disease (MCD). METHODS Over a four year period, surviving children with a diagnosis of MCD had complement activity assessed. A total of 297 children, aged 2 months to 16 yea...
متن کاملMeningococcal infection and proteolytic control.
Cascade enzyme inhibitors (C1-esterase inhibitor, C3b inactivator, antithrombin III) and other major proteolytic enzyme inhibitors (alpha 1 trypsin inhibitor, alpha 1 chymotrypsin inhibitor, inter-alpha-trypsin inhibitor, alpha 2 macroglobulin) as well as C3 and alpha 1 acid glycoprotein, have been examined in the sera of Nigerian patients suffering from meningococcal infection of varied severi...
متن کاملStudies on Meningococcal Infection
From meningococcus Type II broth autolysates, a substance, corresponding to the protective antibody has been isolated. This substance, termed kappa substance, is firmly connected with protein but can be separated by the action of proteolytic enzymes. Methods of preparation and purification are given, together with chemical and serological data. In whole cells from young cultures, this substance...
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ژورنال
عنوان ژورنال: BMJ
سال: 1976
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.1.6013.797